Job Title: Clinical Research Associate
Introduction to role:Are you ready to turn meticulous monitoring and site leadership into faster, higher-quality studies that change how cancer is treated? As a Clinical Research Associate at AstraZeneca, you will own delivery at your assigned sites, ensuring patient safety, data integrity and inspection readiness while driving timelines that matter for patients and the business. How will you use your expertise to accelerate enrolment, reduce queries and elevate site performance?
You will be the primary site contact and a key member of a high-performing local study team. From preparation and initiation through monitoring and close-out, your decisions and follow-through will transform sophisticated protocols into reliable evidence. You will collaborate closely with peers and leaders, share insights across sites, and turn issues into improvements that move pivotal studies forward.
Accountabilities:
- Site Leadership and Relationships: Serve as the main contact for investigators and site staff, building strong partnerships that support timely start-up, sustained recruitment and consistent protocol adherence.
- Study Start-Up and Regulatory Maintenance: In applicable countries, lead or support site qualification, document collection and submissions to Ethics Committees/IRBs and Regulatory Authorities to secure approvals and maintain compliance throughout the study.
- Investigator and Site Training: Train, support and advise investigators and site teams on study requirements and Risk-Based Quality Management principles to keep sites inspection ready at all times.
- Monitoring Excellence: Plan and conduct remote and on-site monitoring visits per the Monitoring Plan; perform Source Data Review, Case Report Form review and Source Data Verification to maintain data quality.
- Data Integrity and Query Resolution: Partner with data management to drive timely query resolution and robust data quality, adapting monitoring intensity based on ongoing Site Quality Risk Assessments.
- Track and share site metrics on enrolment, data timeliness, and quality. Proactively identify issues and implement corrective actions. Report concerns as needed to protect patient safety and study timelines.
- Safety Oversight: Ensure accurate and timely reporting of Serious Adverse Events and follow-ups, reinforcing patient protection and regulatory compliance.
- Systems and Documentation: Update CTMS and other systems within required timelines; ensure timely collection and upload of essential documents to the eTMF and support regular quality checks.
- Supply and Accountability: Oversee site-level study supplies, manage investigational product accountability and coordinate preparation for drug destruction when applicable.
- Inspection Readiness and Audits: Maintain an inspection-ready Investigator Site File; prepare for and collaborate during audits and regulatory inspections in liaison with local leadership and quality partners.
- Collaboration and Knowledge Sharing: Participate actively in local study team meetings and contribute to national investigator meetings; provide market and site insights that inform future studies and feasibility.
- Continuous Improvement: Champion more efficient and effective methods to deliver quality clinical trials with reduced budget and timelines, bringing to bear technology and remote capabilities where appropriate.
Essential Skills/Experience:
- Bachelor degree or equivalent experience in a related field, preferably in life science
- Excellent knowledge of international guidelines ICH-GCP, basic knowledge of GMP/GDP
- Good knowledge of relevant local regulations
- Good medical knowledge and ability to learn relevant AstraZeneca Therapeutic Areas
- Basic understanding of the drug development process
- Good understanding of Clinical Study Management including monitoring, study drug handling and data management
- Excellent attention to details
- Good written and verbal communication skills
- Good collaboration and interpersonal skills
- Good negotiation skills
- Ability to travel nationally/internationally as required
- Ability to work in an environment of remote collaborators
- Manages change with a positive approach for self, team and the business; sees change as an opportunity to improve performance and add customer value to the business
- Ability to look for and champion more efficient and effective methods/processes of delivering quality clinical trials with reduced budget and in less time
- Good analytical and problem-solving skills
- Demonstrates ability to prioritize and manage multiple tasks with conflicting deadlines
- Familiar with risk-based monitoring approach including remote monitoring
- Good cultural awareness
- Ability to understand the impact of technology on projects and to use and develop computer skills while making appropriate use of systems/software in an e-enabled environment
- Team oriented and flexible; ability to respond quickly to shifting demands and opportunities
Desirable Skills/Experience:
- Experience leading or supporting study start-up and regulatory maintenance activities (site qualification, submissions to EC/IRB and Regulatory Authorities)
- Experience contributing to national investigator meetings and regional research group forums
- Proven involvement in audit/inspection preparation and follow-up
- Proficiency with CTMS, eTMF and remote monitoring tools
- Ability to tutor more junior colleagues and take on additional tasks associated with local study leadership
- Valid driving license, if required in your country
When we put unexpected teams in the same room, we ignite ambitious thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Why AstraZeneca:Here, your day-to-day site stewardship fuels a pipeline recognized for its breadth and depth, and your precision helps turn pioneering science into real options for people living with cancer. You will work with colleagues who combine courage and curiosity, using advanced biomarkers, AI-enabled insights, innovative endpoints and modern trial designs to push the field forward. By bringing diverse expertise together in shared spaces, we adapt quickly, learn from each other and stay focused on outcomes that matter for patients. We value kindness alongside ambition, and we back decisive action with the tools, data and collaborative support you need to grow and make a measurable impact.
Call to Action:Ready to translate meticulous monitoring into meaningful advances for patients—while growing your influence across high-impact studies? Submit your application today and help shape what’s next in cancer care.
Date Posted
09-Jun-2026
Closing Date
21-Jun-2026
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
